Figure 9

Venn diagram of genes associated with Autism (RELN-related, blue) and methylation (MECP2-related, yellow) features using a lower threshold for H -matrix in the rank-30 NMF model of the NatRev collection. The resulting genes sets were compared to the 26 autism associated genes reported by Abrams and Geschwind (green). Both the expanded RELN and expanded MECP2 gene sets achieved an F1 score of 0.52 (69% precision, 42% recall), whereas the union of the two gene sets achieved an F1 score of 0.63 (62% precision, 58% recall). Red highlighted genes were new discoveries identified by adjusting the rank-k on the same dataset (Figure 7).