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Figure 3 | BMC Bioinformatics

Figure 3

From: Dynamics of protofibril elongation and association involved in Aβ42 peptide aggregation in Alzheimer’s disease

Figure 3

Reactions towards fibril formation. Approximate set of reactions to model the entire Aβ aggregation pathway. The reactions are grouped into two stages: a) pre-nucleation stage to model the events occurring before nucleation; these set of reactions are slower and assumed to occur primarily through monomer additions to higher end oligomers due to a higher initial concentration of monomers in the system and b) the protofibril elongation stage consists of a faster set of reactions and is approximated by oligomer additions to protofibrils; we do not consider protofibril-protofibril lateral association reactions in this phase as they are not completely captured by ThT fluorescence.

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