Figure 3From: Dynamics of protofibril elongation and association involved in Aβ42 peptide aggregation in Alzheimer’s diseaseReactions towards fibril formation. Approximate set of reactions to model the entire Aβ aggregation pathway. The reactions are grouped into two stages: a) pre-nucleation stage to model the events occurring before nucleation; these set of reactions are slower and assumed to occur primarily through monomer additions to higher end oligomers due to a higher initial concentration of monomers in the system and b) the protofibril elongation stage consists of a faster set of reactions and is approximated by oligomer additions to protofibrils; we do not consider protofibril-protofibril lateral association reactions in this phase as they are not completely captured by ThT fluorescence.Back to article page