Figure 3
Reactions towards fibril formation. Approximate set of reactions to model the entire Aβ aggregation pathway. The reactions are grouped into two stages: a) pre-nucleation stage to model the events occurring before nucleation; these set of reactions are slower and assumed to occur primarily through monomer additions to higher end oligomers due to a higher initial concentration of monomers in the system and b) the protofibril elongation stage consists of a faster set of reactions and is approximated by oligomer additions to protofibrils; we do not consider protofibril-protofibril lateral association reactions in this phase as they are not completely captured by ThT fluorescence.