Figure 9
System dynamics for 60 mins using simple model and varying mapping constant, b . Simulation vs experimental data for protofibril elongation for a longer time-span. Isolated protofibrils were elongated using freshly purified Aβ monomers (green). Simulation plots modeling the elongation phase for longer time-scales (blue) for kfb= 1.08x103 h-1mM-1 and kfb-= 1.2 x101 h-1. These plots were generated by varying the mapping constant b for different initial concentration of protofibrils as follows: b=800 for 2 µM of F, b=1200 for 4 µM of F and b=1700 for 7 µM of F.