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Table 2 Comparison of GOModeler results for the test cytokine dataset with manual analysis results. Columns with the heading G were generated by GOModeler and those with the heading of M were obtained by manual annotation by an immunologist.

From: GOModeler- A tool for hypothesis-testing of functional genomics datasets

Genes

Hypothesis Terms

 

TH2

Antigen Presentation

Chemotaxis

Metastasis

Angiogenesis

T Cell Activation

Cell Proliferation

Apoptosis

 

G

M

G

M

G

M

G

M

G

M

G

M

G

M

G

M

IL-2

1/-1

  

0

1

 

1

 

1/-1

 

1/-1

1

1

1

1/-1

-1

IL-4

1/-1

1

 

1

1

1

  

1/-1

   

1

1

-1

0

IL-6

1

  

0

1

-1

1

0

1

 

1

 

1/-1

0

-1/1

 

IL-8

    

1

1

1

1

1

1

  

-1

-1

1

 

IL-10

1

1

 

1

1

 

1

0

  

-1

 

-1

-1

-1/1

-1

IL-13

 

1

          

1

0

  

IL-18

1

1

     

1

1

1

1

 

1

1

1

1

IFNg

 

-1

-1

1

1

 

1

   

1

 

1/-1

-1

1

1

TGFb

 

1

  

1

 

1

 

1/-1

   

-1

1

1/-1

-1

Effect

Sum of Pro

5

5

0

3

7

2

6

2

6

2

4

1

6

4

7

2

SumofAnti

0

-1

-1

0

0

-1

0

0

0

0

-1

0

-3

-3

-1

-3

Net

5

4

-1

3

7

1

6

2

6

2

3

1

3

1

6

-1