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Table 1 Summary of the data contained in the EDKB database

From: The EDKB: an established knowledge base for endocrine disrupting chemicals

Assay type

Number of records

Standard chemical to be compared

Endpoint

Log (Activity) Range

Estrogen Receptor Binding

616

Estradiol (2.0)

*RBA

From 2.94 to -4.5

Androgen Receptor Binding

230

R1881 (2.0)

RBA

From 3.18 to -3.56

Uterotropic

1707

Estradiol (2.0)

**RP

From 3.93 to -3.44

Cell proliferation

160

Estradiol (2.0)

***RPP

From 3.0 to -4.22

Reporter gene

544

Estradiol (2.0)

RP

From 2.18 to -5.38

  1. A summary of the distribution of data, standard chemicals to be compared, endpoints, and activity ranges.
  2. The values in parentheses are log activity for a standard chemical
  3. * RBA: Relative Binding Affinity
  4. ** RP: Relative Potency
  5. *** RPP: Relative Proliferation Potency