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Table 1 Top ten functions/diseases and their respective top ten pathways in ncp BVDV- infected monocytes

From: Analysis of Bovine Viral Diarrhea Viruses-infected monocytes: identification of cytopathic and non-cytopathic biotype differences

  Acute phase response signaling (8) Caveolae- mediated endocytosis signaling (5) B cell development (3) IL-10 signaling(3) Macropinocytosis signaling (3) Virus entry via endocytic pathway (3) Antigen presentation pathway (2) Fcy receptor mediated phagocytosis in macrophages and monocytes (3) Integrin signaling (4) Primary immunodeficiency signaling (2)
Cellular movement (10)   ITGB3 SPN CSF1R, ITGB3 ITGB3 FGR ITGB3
Immune cell trafficking (18) ITGA6, ITGB3 SPN, PTPRC CD14 CSF1R, ITGB3, CD14 ITGA6, ITGB3 FGR ITGA6, ITGB3 PTPRC
Inflammatory response(20) TF ITGA6, ITGB3 SPN, PTPRC CD14 CSF1R, ITGB3, CD14 ITGA6, ITGB3 FGR ITGA6, ITGB3 PTPRC
Cell death (11) SOD2 PTPRC, HLA- DRB1 CD14 CSF1R, ITGB3 HLA-DRB1 FGR   PTPRC
Hematological systemdevelopment and function (21) TF ITGA6, ITGB3 SPN, PTPRC, HLA-DRB1 CD14 CSF1R, ITGB3, CD14 ITGA6, ITGB3 FGR ITGA6, ITGB3 PTPRC
Cell-to-cell signaling and interaction (10) ITGB3 PTPRC CD14 CSF1R, ITGB3, CD14 ITGB3 FGR ITGB3 PTPRC
Cellular function and maintenance (5) ITGB3 ITGB3 ITGB3 FGR ITGB3
Immunologicaldisease (5) PTPRC CD14 CD14 PTPRC
Antigenpresentation (13) A2M PTPRC CD14 CSF1R, CD14 FGR
Inflammatorydisease (5) ITGB3 PTPRC ITGB3 ITGB3 ITGB3 PTPRC
  1. TF: Transferrin; SOD2: Superoxide Dismutase 2, mitochondrial; A2M: Alpha-2-Macroglobulin; ITGB6: Integrin, Beta 6; ITGB3: Integrin, Beta 3 (platelet glycoprotein IIIa, antigen CD61); SPN: Sialophorin; PTPRC: Protein Tyrosine Phosphatase, Receptor type, C; CSF1R: Colony Stimulating Factor 1 Receptor; FGR: Fibrinogen Gamma Chain Numbers between brackets indicates the number of altered proteins involved in the functions/diseases or pathway