Table 1 Top ten functions/diseases and their respective top ten pathways in ncp BVDV- infected monocytes
| Â | Acute phase response signaling (8) | Caveolae- mediated endocytosis signaling (5) | B cell development (3) | IL-10 signaling(3) | Macropinocytosis signaling (3) | Virus entry via endocytic pathway (3) | Antigen presentation pathway (2) | Fcy receptor mediated phagocytosis in macrophages and monocytes (3) | Integrin signaling (4) | Primary immunodeficiency signaling (2) |
|---|---|---|---|---|---|---|---|---|---|---|
Cellular movement (10) |  | ITGB3 | SPN | – | CSF1R, ITGB3 | ITGB3 | – | FGR | ITGB3 | – |
Immune cell trafficking (18) | – | ITGA6, ITGB3 | SPN, PTPRC | CD14 | CSF1R, ITGB3, CD14 | ITGA6, ITGB3 | – | FGR | ITGA6, ITGB3 | PTPRC |
Inflammatory response(20) | TF | ITGA6, ITGB3 | SPN, PTPRC | CD14 | CSF1R, ITGB3, CD14 | ITGA6, ITGB3 | – | FGR | ITGA6, ITGB3 | PTPRC |
Cell death (11) | SOD2 | – | PTPRC, HLA- DRB1 | CD14 | CSF1R, ITGB3 | – | HLA-DRB1 | FGR |  | PTPRC |
Hematological systemdevelopment and function (21) | TF | ITGA6, ITGB3 | SPN, PTPRC, HLA-DRB1 | CD14 | CSF1R, ITGB3, CD14 | ITGA6, ITGB3 | – | FGR | ITGA6, ITGB3 | PTPRC |
Cell-to-cell signaling and interaction (10) | – | ITGB3 | PTPRC | CD14 | CSF1R, ITGB3, CD14 | ITGB3 | – | FGR | ITGB3 | PTPRC |
Cellular function and maintenance (5) | – | ITGB3 | – | – | ITGB3 | ITGB3 | – | FGR | ITGB3 | – |
Immunologicaldisease (5) | – | – | PTPRC | CD14 | CD14 | – | – | – | – | PTPRC |
Antigenpresentation (13) | A2M | – | PTPRC | CD14 | CSF1R, CD14 | – | – | FGR | – | – |
Inflammatorydisease (5) | – | ITGB3 | PTPRC | – | ITGB3 | ITGB3 | – | – | ITGB3 | PTPRC |