Table 2 Top ten functions/diseases and their respective top ten pathways in cp BVDV- infected monocytes
| Â | Acute phase response signaling(12) | Fcy receptor mediated phagocytosis in macrophages and monocytes (8) | Actin cytoskeleton signaling (8) | Antigen presentation pathway (3) | B cell development (3) | RhoA signaling(5) | Caveolae- mediated endocytosis signaling (4) | Clathrin- mediated endocytosis signaling (6) | IL-10 signaling(3) | Interferon signaling(2) |
|---|---|---|---|---|---|---|---|---|---|---|
Cellular function and maintenance (7) | – | FGR, LYN | – | – | – | – | ITGB3 | ITGB3 | – | – |
cell-to-cell signaling and interaction (8) | F2 | FGR, LYN | CD14, F2 | – | – | – | ITGB3 | F2, ITGB3 | CD14 | – |
Inflammatory response (14) | F2 | FGR, LYN | CD14, F2 | TAPBP | HLA-DQB1 | – | ITGB3 | F2, ITGB3 | CD14 | – |
Cellular assembly and organization (2) | – | FGR, LYN | – | – | – | – | – | – | – | – |
Protein synthesis (2) | – | FGR, LYN | – | – | – | – | – | – | – | – |
Cellular compromise (6) | – | FGR, LYN | – | – | – | – | ITGB3 | ITGB3 | – | – |
Cell morphology (3) | – | FGR, LYN | – | – | – | – | – | – | – | – |
Cellular development (4) | – | FGR, LYN | – | – | – | – | ITGB3 | ITGB3 | – | – |
Hematological system development and function (9) | F2 | FGR, LYN | CD14, F2 | – | SPN | – | ITGB3 | F2, ITGB3 | CD14 | – |
Immune cell trafficking (9) | F2 | FGR, LYN | F2 | – | SPN | – | ITGB3 | F2, ITGB3 | – | – |