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Table 3 Differentially altered proteins represented in top ten immunological pathways when comparing cp to ncp BVDV infection

From: Analysis of Bovine Viral Diarrhea Viruses-infected monocytes: identification of cytopathic and non-cytopathic biotype differences

  

Regulation

 

Symbol

Entrez Gene Name

Cp

Ncp

Pathways

HMOX1

heme oxygenase (decycling) 1

Up

Up

Acute Phase Response Signaling, Fcy Receptor-mediated Phagocytosis in

    

Macrophages and Monocytes, IL-10 Signaling

ALB

albumin

Down

Down

Acute Phase Response Signaling, Caveolar-mediated Endocytosis Signaling

HP

haptoglobin

Down

Down

Acute Phase Response Signaling

SOD2

superoxide dismutase 2, mitochondrial

Up

Up

Acute Phase Response Signaling

TF

transferrin

Up

Up

Acute Phase Response Signaling, Clathrin-mediated Endocytosis Signaling

APOH

apolipoprotein H (beta-2-glycoprotein I)

Up

Acute Phase Response Signaling

APOA1

apolipoprotein A-I

Up

Acute Phase Response Signaling

AHSG

alpha-2-HS-glycoprotein

Up

Up

Acute Phase Response Signaling

SERPINA1

serpin peptidase inhibitor, clade A (alpha-1

Up

Up

Acute Phase Response Signaling

 

antiproteinase, antitrypsin), member 1

   

A2M

alpha-2-macroglobulin

Up

Up

Acute Phase Response Signaling

FGG

fibrinogen gamma chain

Up

Acute Phase Response Signaling

F2

coagulation factor II (thrombin)

Up

 

Acute Phase Response Signaling, Actin Cytoskeleton Signaling, Clathrin-

    

mediated Endocytosis Signaling

ACTR3

ARP3 actin-related protein 3 homolog (yeast)

Up

Up

Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes, Actin

    

Cytoskeleton Signaling, RhoA Signaling, Clathrin-mediated Endocytosis

    

Signaling

ARPC2

actin related protein 2/3 complex, subunit 2,

Up

 

Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes, Actin

 

34kDa

  

Cytoskeleton Signaling, RhoA Signaling, Clathrin-mediated Endocytosis

    

Signaling

EZR

ezrin

Down

 

Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes, Actin

    

Cytoskeleton Signaling, RhoA Signaling

LYN

v-yes-1 Yamaguchi sarcoma viral related

Up

 

Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes

 

oncogene homolog

   

TLN1

talin 1

Down

Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes

FYB

FYN binding protein (FYB-120/130)

Down

Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes

FGR

Gardner-Rasheed feline sarcoma viral (v-fgr)

Down

Down

Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes

 

oncogene homolog

   

MYH10

myosin, heavy chain 10, non-muscle

Up

Actin Cytoskeleton Signaling

MYL6

myosin, light chain 6, alkali, smooth muscle and

Up

 

Actin Cytoskeleton Signaling, RhoA Signaling

 

non-muscle

   

DIAPH3

diaphanous homolog 3 (Drosophila)

Down

Actin Cytoskeleton Signaling

CD14

CD14 molecule

Up

Up

Actin Cytoskeleton Signaling, IL-10 Signaling

IQGAP1

IQ motif containing GTPase activating protein 1

_

Up

Actin Cytoskeleton Signaling

HLA-DRB1

major histocompatibility complex, class II, DR

Up

Up

Antigen Presentation Pathway, B Cell Development

 

beta 1

   

TAP1

transporter 1, ATP-binding cassette, sub-family

Down

Down

Antigen Presentation Pathway, Interferon Signaling

 

B (MDR/TAP)

   

TAPBP

TAP binding protein (tapasin)

Down

Antigen Presentation Pathway

HLA-DQB1

major histocompatibility complex, class II, DQ

Down

 

B Cell Development

 

beta 1

   

SPN

sialophorin

Down

Down

B Cell Development

PTPRC

protein tyrosine phosphatase, receptor type, C

_

Up

B Cell Development

KTN1

kinectin 1 (kinesin receptor)

Down

Down

RhoA Signaling

ITGA2B

integrin, alpha 2b (platelet glycoprotein IIb of

Up

Down

Caveolae-mediated Endocytosis Signaling

 

IIb/IIIa complex, antigen CD41)

   

FLNA

filamin A, alpha

Up

Up

Caveolae-mediated Endocytosis Signaling

ITGB3

integrin, beta 3 (platelet glycoprotein IIIa,

Up

Down

Caveolae-mediated Endocytosis Signaling, Clathrin-mediated Endocytosis

 

antigen CD61)

  

Signaling

ITGA6

integrin, alpha 6

Down

Caveolae-mediated Endocytosis Signaling

SH3GLB1

SH3-domain GRB2-like endophilin B1

Down

Clathrin-mediated Endocytosis Signaling

ARG2

arginase, type II

Up

Up

IL-10 Signaling

MX1

myxovirus (influenza virus) resistance 1,

Up

 

Interferon Signaling

 

interferon-inducible protein p78 (mouse)