Figure 4
From: Analysis and verification of the HMGB1 signaling pathway
HMGB1 and AKT sensitivity study. Overexpression of HMGB1 (A-B, D-E) leads to the increase of oncoprotein E2F and DNA replication proteins CyclinD/E, and to the decrease of p53. Overexpression of AKT (C, F) activated by HMGB1 increases the expression level of MDM2 p and represses p53, using ODE (A-C) and SSA (D-F) simulations.