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Table 1 Centrality measurements for the RNA targets in the protein-protein interaction network

From: Modularity of Escherichia coli sRNA regulation revealed by sRNA-target and protein network analysis

 

All

Experimental

Experimental and predicted

 

mean

mean

Sim.

mean

p-val

mean

Sim.

mean

p-val

Deg

7.9

11

7.9

0.16

7.0

7.9

0.66

Bet

2.2e-03

4.2e-3

2.2e-3

0.098

2.2e-3

2.2e-3

0.44

Clo

0.28

0.3

0.28

0.022

0.27

0.28

0.59

CC

0.11

0.21

0.11

0.037

0.12

0.10

0.20

CPL

3.7

2.6

3.7

0.015

3.6

3.7

0.23

Den

6.5e-03

0.14

6.5e-3

0.019

0.063

6.2e-3

0.028

IDR

N/A

6.5e-3

3.4e-4

9.0e-3

5.8e-3

5.0e-4

0.011

I/T

 

28/65

85/240

  

Experimental & extended

Exp & pred & both extended

Deg

 

Mean

Sim.

mean

p-val

Mean

Sim.

mean

p-val

Deg

 

9.3

7.9

0.28

7.4

7.9

0.62

Bet

 

3.4e-3

2.2e-3

0.14

2.0e-3

2.2e-3

0.57

Clo

 

0.29

0.28

0.051

0.27

0.28

0.87

CC

 

0.19

0.11

0.027

0.14

0.10

0.017

CPL

 

3.0

3.7

0.020

3.4

3.7

5.0e-3

Den

 

0.085

7.0e-3

0.015

0.14

5.8e-3

0.0

In-d

 

4.0e-3

5.5e-4

0.032

9.5e-2

7.9e-4

0.0

I/T

 

38/92

144/450

  1. Those with significant values (p < 0.05) are indicated in boldface and those close to a p-value of 0.05 are underlined. The extended targets are targets located downstream of experimental or predicted sRNA targets in the same operon. Deg: Degree, Bet: Betweenness, Clo: Closeness, CC, Clustering coefficient, CPL: Characteristic path length Pat: Path length, Den: Density, IDR, In-degree ratio, I/T: sRNA in the network/total sRNA