Identification of a better Homo sapiens Class II HDAC inhibitor through binding energy calculations and descriptor analysis

Table 3 Toxicity risks of SAHA and TSA

	Toxicity Risks
Inhibitor	Mutagenic	Tumorigenic	Irritant	Reproductive Effective
Suberoyl anilide hydroxamic acid (SAHA)	yellow	green	green	green
Trichostatin A (TSA)	yellow	red	green	green

Prediction results are color coded. Properties with high risks of undesired effects like mutagenicity or a poor intestinal absorption are shown in red. Whereas a green color indicates drug-conform behaviour. From Table 3, TSA was lacking (red color) in one property. SAHA was the compound that had the acceptable range (green color) for tumorigenic, irritant, and reproductive effective.

ISSN: 1471-2105