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Figure 1 | BMC Bioinformatics

Figure 1

From: DODO: an efficient orthologous genes assignment tool based on domain architectures. Domain based ortholog detection

Figure 1

Species closeness and gene length of the ortholog groups identified with DODO. There are two set of ortholog groups identified with DODO, when compare to HomoloGene database. One set of them (n = 8507) has same classification as HomoloGene and the other set of them (n = 9695) has different classification from HomoloGene. (A) The closeness of each ortholog group in these two sets was calculated according to the similarity of taxonomy as described in NCBI. The set of same classification was significantly higher than the different set (wilcoxon test, p-value < 2.2e-16). This result shows that part of ortholog groups identified with DODO contains putative orthodox from distantly related species. (B) The average gene length was calculated for each ortholog group in either the same classification or different classification set. The set of same classification had significantly longer average gene length than different classification set (wilcoxon test, p-value = 8.93e- 10). This implied that DODO did find some ortholog groups composed of shorter sequences. Those shorter sequences may contain insufficient information; therefore, their orthologous relationship could not be found by conventional RBH ortholog detection method.

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