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Table 3 Co-occurrence of Pfam domains in IDD clusters

From: Intrinsically disordered domains deviate significantly from random sequences in mammalian proteins

Immune Obs./Expect Non-immune Obs./Expect Short Name Full Name Function (Uniref ID)
1 (5/30) 2.54 18 (3/11) 3.12 SH2 SH2 domain Signal transduction (P05480)
3 (3/11) 5.06 41 (2/20) 2.75 C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) RNA binding & signal transduction (P97433)
6 (2/3) 16.90 18 (5/21) 2.72 Guanylate_kin Guanylate kinase Possible Signal transduction (B9EHJ3 )
6 (2/25) 2.03 18 (3/11) 3.12 bZIP_1 bZIP transcription factor Transcription (P01101)
38 (3/25) 6.35 31 (3/40) 4.83 SH3_1 SH3 domain Adaptor (Q64010)
72 (2/15) 5.00 55 (2/30) 2.53 7tm_1 7 transmembrane receptor (rhodopsin family) GPCR (O09047)
100 (2/33) 7.27 38 (6/48) 2.88 zf-C2H2 Zinc finger, C2H2 type Possible transcription regulator (Q8C687)
100 (2/10) 24.00 38 (3/10) 6.90 KRAB KRAB box Possible transcription regulator (Q8BIV1)
115 (1/5) 7.35 26 (2/6) 2.94 ARID ARID/BRIGHT DNA binding domain Possible transcription regulator (Q3U108)
175 (2/12) 12.50 2 (2/13) 5.16 fn3 Fibronectin type III domain Putative neuronal cell adhesion molecule (Q8BQC3)
  1. A subset of all 51 co-occurring Pfam domains is listed. Columns 1-2 and 3-4 describe the immune and non-immune clusters, respectively. The first number is the cluster index, and the numbers in parentheses are the number of occurrences of the Pfam domain of interest and the total number of Pfam domains in the cluster, respectively. The 2nd and 4th columns are the ratio of the observed to expected number of Pfam domains in the cluster of interest, where the expected number is given by eqn. 5.