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Figure 1 | BMC Bioinformatics

Figure 1

From: Stromal microenvironment processes unveiled by biological component analysis of gene expression in xenograft tumor models

Figure 1

Description of the Biological Component Analysis Part A: To derive the possible contribution of the stromal microenvironment from the cross-hybridizing probes, we studied gene lists derived from xenograft models from the literature that used the same microarray platform. Robust GO enrichment analyses[20] were conducted over (i) all genes differentially expressed between the experimental conditions, (ii) the cross-hybridizing subset, or (iii) the remaining genes (A, Top Venn Diagram). Part B: We evaluated the cross-hybridizing genes enriched GO terms with expert classified GO terms and with the gold standards from literature (Bottom Venn Diagrams). Legend: Hs: Homo sapiens; Mm: Mus musculus; P: Probe; GS: gold standard.

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BMC Bioinformatics

ISSN: 1471-2105

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