Table 2 Exemplary intersection between gene co-expression, knowledge-anchored, and clinical feature co-expression networks, as identified during Phase 2.
From: Multi-dimensional discovery of biomarker and phenotype complexes
Network | Initial Concept | Network Path or CKC | Terminal Concept |
|---|---|---|---|
Gene Co-Expression* | CD8A | CD8A↔IL2RB↔ZAP70 | ZAP70 |
Conceptual Knowledge** | ZAP70 | [ZAP70 gene]-gene_plays_role_in_process-[Ligand Binding]-biological_process_involves_gene_product-[LTB4R protein, human]-gene_product_expressed_in_tissue-[Lymphoid Tissue]-is_normal_tissue_origin_of_diseas e-[Chronic lymphocytic leukaemia refractory] | Chronic lymphocytic leukemia refractory |
Clinical Feature Co-Expression* | Chronic lymphocytic leukemia refractory | Chronic lymphocytic leukemia refractory (treatment response) ↔ del(17p13) ↔ Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene ↔ Lactic acid dehydrogenase raised | Lactic acid dehydrogenase raised |