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Table 1 Knowledge filtered significant SNPs

From: An integrative method for scoring candidate genes from association studies: application to warfarin dosing

SNP Gene Name P-Value
rs10871454 VKORC1 Vitamin K1 2,3-epoxide reductase subunit 1 9.31E-10
rs4086116 CYP2C9 cytochrome P450, family 2, subfamily C 7.54E-05
rs4917639 CYP2C9 cytochrome P450, family 2, subfamily C 9.47E-05
rs9332169 CYP2C9 cytochrome P450, family 2, subfamily C 2.33E-04
rs9332214 CYP2C9 cytochrome P450, family 2, subfamily C 2.33E-04
rs10509680 CYP2C9 cytochrome P450, family 2, subfamily C 2.33E-04
rs12445568 HSD3B7 3-beta-HSD VII 3.84E-04
rs12357515 EXOC6 Exocyst complex component Sec15A 3.86E-04
rs11187215 EXOC6 Exocyst complex component Sec15A 3.87E-04
rs7294 VKORC1 Vitamin K1 2,3-epoxide reductase subunit 1 4.15E-04
  1. Top 10 of 3,856 SNPs fitting a univariate linear regression model of warfarin dose for 181 patients. Bold SNPs are significant after multiple hypothesis testing. Only rs10871454 (a SNP in 100% LD with VKORC1) was significant after correcting for multiple hypothesis testing.