Table 1 The drug characteristics and their data sources
Data source | Characteristic category | Examples | Number of characteristics | Median number of drugs associated with the characteristic |
|---|---|---|---|---|
Australian Medicines Handbook (AMH) | Major drug classes | Gastrointestinal drugs, Anti-infectives, Cardiovascular drugs | 20 | 37 |
| Â | Minor drug classes | 5HT3 antagonists, Benzodiazepines, Carbapenems, Platinum compounds, Taxanes | 197 | 3 |
| Â | Adverse events | Anorexia, EPSE, Hyperuricaemia, Increased liver enzymes, Nephrotoxicity | 238 | 22 |
Pharmacokinetic Interaction Screening tool (PKIS) | Perpetrators* | CYP1A2 inducers, CYP3A inducers CYP3A inhibitors (moderate), CYP3A inhibitors (strong) | 15 | 5 |
| Â | Narrow therapeutic index drugs | Alkylating agents, Anticonvulsants, Immunosuppresants, | 14 | 5.5 |
Total | Â | Â | 484 | Â |