Table 4 Drug characteristics with poorly discriminative index keywords but achieved an overall good predictive performance
Category | Characteristic | Position of IK(s) | n(pos) | Best AUC* | Top-20 predictive tokens/words (AUC†) |
|---|---|---|---|---|---|
AE | Cystitis | 10.7 pct | 13 | 1.000 | nsaids, cyclooxygenase, nimesulide, meloxicam (0.999); nsaid, diclofenac, naproxen, antiinflammatory, non-steroidal (0.998); ibuprofen, anti-inflammatory, nonsteroidal (0.997); ketoprofen, antipyretic (0.996); indomethacin (0.993); osteoarthritis (0.991); pge2 (0.991), prostanoid (0.988), thromboxane (0.986), prostaglandin (0.985) |
AE | Dyslipidaemia | 14.0 pct | 13 | 0.900 | Aldosterone (0.95); acetazolamide, mineralocorticoid (0.94); deoxycorticosterone (0.93), pge2, indomethacin, hearing (0.88); spironolactone, mineralocorticoids, hyponatremia, renin, adh, ace (0.87); furosemide (0.86); insipidus, asthmatic, prostaglandins, fev1, pra, phenylbutazone (0.85) |
AE | Migraine | 76.0 pct | 14 | 0.906 | angiotensin (0.89), plasminogen, dbp, insulin (0.85); infarction, low-density, losartan (0.84); hormonal, brachial, run-in, fixed-dose (0.83); lipoprotein, valsartan, endothelium-dependent, renin (0.82); pravastatin, hba1c (0.81); angiotensinogen, chd, smoking (0.80) |
AE | Oesophagitis | 10.0 pct | 19 | 0.919 | Metastases (0.92); marrow (0.90); weekly (0.88); metastatic, antitumor (0.87); cancer (0.86); 3-year, toxicity, regimen, nadir, breast, metastasis (0.85); myeloma, survival, cancers, prostate (0.84); regimens, remission, cytotoxic, melphalan (0.83) |
AE | Paralytic ileus | 59.4 pct | 12 | 0.961 | amitriptyline (0.96); tricyclic (0.95); antidepressants, anticholinergic, antidepressant (0.94); neuroleptics, chlorpromazine, depressive, overdose (0.93); tca, serotonin, diazepam (0.92); intoxication (0.91); thioridazine, clonidine (0.90); psychotropic, affective, psychological, antinociceptive (0.89); constipation (0.87) |
AE | Thrombocytopenic purpura | 10.6 pct | 11 | 1 | infarction, ejection (0.95); intra-arterial (0.94); echocardiography (0.93); st-segment (0.93); echocardiographic (0.90); beta-blocking (0.89); beta-blocker (0.87); cardiology, diacetolol, bopindolol, bucindolol, beta-adrenoceptor-blocking, adp, beta-ars, beta1-selective, beta-adrenoblockers, cardioselectivity, atenolol, non-fatal (0.86) |
MC | 5HT3 antagonists | 10.0 pct | 4 | 1 | 5-ht3ra, 5-ht3ra/dexamethasone, granisetron, ondansetron, 1966-september, 5-ht3, tropisetron, 5-hydroxytryptamine3, anti-emetic (1); dolasetron, emetic, ramosetron, 5-ht3-receptor, cinv, 5ht3, emetogenic, type-3, emesis, setrons, pov (0.999) |
MC | Antibacterials (ear) | 14.7 pct | 4 | 0.98 | enrofloxacin, chloramphenicol, gentamycin (0.99); oxytetracycline, kanamycin, polymyxin, colistin, gentamicin, bacitracin, neomycin, povidone-iodine, fusidic, streptomycin, bacterial, septicemia, swabs (0.98); anaerobic, peru, tetracycline, aminoglycoside (0.97) |