Table 5 Comparative evaluation of cdf-based predictions with other commonly used IR methods
Category | Best AUC | Method | ||||
|---|---|---|---|---|---|---|
| Â | Â | cdf | ctf | ctf-icdf | Stemming | Synonyms |
AMH major classes | > 0.80 | 20 (100) | 20 (100) | 20 (100) | 19 (95) | 20 (100) |
| Â | > 0.90 | 19 (95) | 17 (85) | 18 (90) | 17 (85) | 18 (90) |
| Â | > 0.95 | 12 (60) | 12 (60) | 15 (75) | 12 (60) | 11 (55) |
AMH minor classes | > 0.80 | 135 (69) | 106 (54)* | 157 (80) | 152 (77) | 156 (79) |
| Â | > 0.90 | 123 (62) | 100 (51) | 150 (76)* | 145 (74) | 151 (77)* |
| Â | > 0.95 | 114 (58) | 92 (47) | 144 (73)* | 142 (72)* | 143 (73)* |
AMH adverse events | > 0.80 | 159 (67) | 148 (62) | 173 (73) | 153 (64) | 155 (65) |
| Â | > 0.90 | 86 (36) | 88 (37) | 100 (42) | 84 (35) | 84 (35) |
| Â | > 0.95 | 41 (17) | 42 (18) | 55 (23) | 44 (18) | 44 (18) |
PKIS perpetrator | > 0.80 | 7 (47) | 6 (40) | 7 (47) | 12 (80) | 10 (67) |
| Â | > 0.90 | 5 (33) | 5 (33) | 4 (27) | 3 (20) | 4 (27) |
| Â | > 0.95 | 2 (13) | 2 (13) | 2 (13) | 3 (20) | 3 (20) |
Narrow therapeutic index drugs | > 0.80 | 9 (64) | 9 (64) | 11 (79) | 10 (71) | 10 (71) |
| Â | > 0.90 | 8 (57) | 7 (50) | 10 (71) | 9 (64) | 10 (71) |
| Â | > 0.95 | 5 (36) | 6 (43) | 9 (64) | 9 (64) | 10 (71) |
Overall | > 0.80 | 330 (68) | 289 (60)* | 368 (76)* | 346 (71) | 351 (73) |
| Â | > 0.90 | 241 (50) | 217 (45) | 282 (58)* | 258 (53) | 267 (55) |
| Â | > 0.95 | 174 (36) | 154 (32) | 225 (46)* | 210 (43) | 211 (44) |