Figure 3

Typical plots of the cumulative distribution functions (CDF) of sample variances. In these plots, σ _Ω is a calculated sample variance for any combination of n amino acids and p _Ω is the associated probability of obtaining such sample variance value for the property Ω just randomly choosing n amino acids, and CDF profiles vary depending on the number of amino acids selected. Continuing with the example of Figure 2, the sample variance σ _9,Ω,6 has an associated probability p _9,Ω,6 that can be found using the corresponding CDF_{Ω, n}.