Figure 5From: Mutagenesis Objective Search and Selection Tool (MOSST): an algorithm to predict structure-function related mutations in proteinsScheme depicting the calculation of differences Δσi,(Ωr,Ωs),nbetween pairs of sample variances for a VDP. Large paired differences exist maximally only when one property is strictly conserved while the others are not. This is exploited to combine evidence by integrating individual significances from different pairs of properties.Back to article page