BMC Bioinformatics

Table 3 Simulated FDR and Power Rate (10 Analyses τ = 5%)

From: Sequential interim analyses of survival data in DNA microarray experiments

	Analysis
	1		2		3		4		5
	mean	sd	mean	sd	mean	sd	mean	sd	mean	sd
#found genes	0	0	0	1	2	10	18	38	99	78
FDR	0.015	0.119	0.049	0.210	0.104	0.292	0.063	0.170	0.062	0.091
APR	0.000	0.000	0.000	0.001	0.003	0.019	0.033	0.070	0.185	0.146
	0.036	0.038	0.032	0.067	0.004	0.022	0.030	0.063	0.168	0.142
(S)	0.038	0.047	0.034	0.090	0.005	0.030	0.032	0.082	0.177	0.182
(L)	0.292	0.403	0.441	0.221	0.409	0.115	0.511	0.125	0.623	0.123
	6		7		8		9		10
	mean	sd	mean	sd	mean	sd	mean	sd	mean	sd
#found genes	215	70	284	49	318	38	333	31	332	27
FDR	0.056	0.030	0.056	0.017	0.055	0.015	0.055	0.014	0.055	0.014
APR	0.406	0.132	0.537	0.092	0.601	0.070	0.629	0.058	0.627	0.049
	0.362	0.152	0.471	0.139	0.526	0.142	0.549	0.147	0.551	0.153
(S)	0.373	0.220	0.486	0.224	0.522	0.215	0.539	0.217	0.543	0.221
(L)	0.702	0.119	0.746	0.114	0.765	0.109	0.774	0.113	0.772	0.113

The descriptive values for each interim analysis including the number detected genes, the simulated FDR, the real APR, and the APR estimates, all in the setting of τ = 5% altered genes and ten interim analyses.

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