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Table 5 Simulated FDR and Power Rates (Parameters from the Breast Cancer Data)

From: Sequential interim analyses of survival data in DNA microarray experiments

  Analysis
  1 2 3 4 5
  mean sd mean sd mean sd mean sd mean sd
#found genes 0 0 0 0 14 34 701 227 1650 396
FDR 0.000 0.000 0.000 0.000 0.074 0.179 0.035 0.008 0.034 0.005
APR 0.000 0.000 0.000 0.000 0.002 0.004 0.079 0.026 0.186 0.045
0.000 0.000 0.100 0.160 0.004 0.008 0.117 0.031 0.234 0.044
(S) 0.000 0.000 0.118 0.238 0.003 0.007 0.107 0.029 0.217 0.043
(L) 0.000 0.000 0.443 0.374 0.371 0.032 0.514 0.030 0.591 0.029
  6 7 8 9 10
  mean sd mean sd mean sd mean sd mean sd
#found genes 2005 413 2318 457 2614 442 2906 447 3107 439
FDR 0.034 0.005 0.033 0.005 0.033 0.005 0.034 0.004 0.033 0.004
APR 0.227 0.046 0.262 0.051 0.296 0.050 0.329 0.050 0.352 0.050
0.275 0.046 0.308 0.050 0.341 0.048 0.371 0.048 0.392 0.046
(S) 0.259 0.046 0.289 0.051 0.324 0.049 0.354 0.050 0.375 0.051
(L) 0.617 0.029 0.631 0.029 0.648 0.029 0.664 0.030 0.675 0.032
  1. The descriptive values for each interim analysis including the number detected genes, the simulated FDR, the real APR, and the APR estimates, all in the setting where parameters were taken from the breast cancer data.