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Table 2 Performance of different methods based on an independent dataset.

From: Predicting disease-associated substitution of a single amino acid by analyzing residue interactions

Methods

Sensitivity (%)

Specificity (%)

ACC (%)

MCC

All feature set

86.6

71.9

80.8

0.59

37-feature set

87.3

72.1

81.3

0.60

SIFT

79.5

71.3

76.3

0.51

PolyPhen-2

74.1

78.1

75.7

0.51

Bongo

21.6

84.7

46.6

0.09