Pairwise predictions deduced from 198 modules compared with predictions of the co-occurrence baseline method. The Venn diagram visualizes the overlaps between the different OG pair sets. The partitions are defined over OG pairs. For each section of the Venn diagram, the number of distinct OG terms defined as parts of the pairs is noted. Note that the OG sets of the single sections are not necessarily disjoint. A large total of 5,123 pairs have been validated for the modules. Additionally, 7,603 first-order transitive relationships could be validated based on the reference set (not included in the Venn diagram). Based on our estimate E[h] for the expected number h of random matches for a single module, we would expect less than 50 matches to the reference set for the 42,695 tested pairs of the modules by chance.