Focal aberrations in GBM data with several M values. Focal aberrations of GBM data  are shown. and its corresponding p-values are generated using M values from 9 to 15. (a)-(b) On the left, p-values of are drawn across chromosomes with GBM related genes for M values of 9 and 12. Deletions (amplifications) are represented in blue (red). On the right, statistically significant clusters with GBM related gene symbols are shown. For example, in (a), 71 clusters are generated and the top seven clusters include seven GBM genes. These clusters span 436 MB chromosomal regions in total. Clusters with deletions (amplifications) are represented in blue (red). As M increases, the number of clusters decreases. Although the values of M change, GBM genes are still located in the highly ranked clusters. When M = 12, a cluster containing RB1 (MDM4) is indicated in light blue (light red), which denotes that RB1 (MDM4) lies slightly out of the cluster. (c)-(g) Clusters with M values of 10, 11, 13, 14, and 15 are shown for GBM genes.