Chr18:18-62 MB regions. Both GISTIC and WIFA identify amplifications in chr18:20,300-23,559 KB, whereas amplifications in chr18:43,954-45,322 KB including SMAD7 are only identified by WIFA. (a) log2 ratios of two patients amplified in chr18:43,954-45,322 KB are shown. (b) G-scores in the same region by GISTIC are not large enough to be identified. (c) by WIFA is significantly higher in the same region.