|
Score
|
P
cluster
|
Cytoband
|
Start (KB)
|
End (KB)
|
# of PA
|
Gene Symbol§
|
|---|
|
118
|
0
|
14q13.2 q13.3
|
35,467
|
36,690
|
10
|
MBIP,NKX2-1
|
|
107
|
0
|
12p11.23 p12.1
|
24,055
|
26,685
|
4
|
KRAS
|
|
84
|
0
|
18q11.2 q12.1
|
20,300
|
23,537
|
4
|
SS18
|
|
62
|
0
|
7p11.2 p12.1
|
53,796
|
55,553
|
3
|
EGFR
|
|
54
|
0.006
|
18q21.1
|
43,971
|
45,322
|
2
|
SMAD7 ‡
|
|
51
|
0.064
|
12q15
|
67,983
|
69,669
|
4
|
MDM2 †
|
|
47
|
0.006
|
19q12
|
35,835
|
36,303
|
2
|
CCNE1 †
|
|
47
|
0
|
11q13.2 q13.3
|
68,164
|
69,500
|
3
|
CCND1
|
|
42
|
0.012
|
19q13.11 q13.12
|
37,716
|
41,040
|
5
| |
|
35
|
0
|
22q11.21
|
19,057
|
19,785
|
2
| |
|
33
|
0
|
17q12 q21.1
|
33,845
|
35,540
|
4
|
ERBB2
|
|
26
|
0.018
|
8p11.23 p12
|
38,417
|
39,171
|
2
|
FGFR1
|
|
24
|
0
|
10p11.21
|
37,594
|
38,717
|
2
| |
|
22
|
0
|
6p21.33
|
30,143
|
30,911
|
2
| |
|
15
|
0.023
|
6p22.1 p22.2
|
26,089
|
26,937
|
2
| |
|
14
|
0.007
|
5p12
|
42,982
|
44,452
|
2
|
FGF10 ‡
|
|
10
|
0.064
|
6p21.1
|
43,240
|
44,227
|
2
|
VEGFA
|
|
10
|
0.019
|
10q11.21
|
42,184
|
43,133
|
2
| |
|
9
|
0
|
9p21.3
|
24,546
|
25,375
|
2
| |
|
-3
|
0
|
9p21.3
|
21,181
|
22,194
|
2
|
CDKN2A
|
- When M = 11, 20 statistically significant clusters are shown. These clusters contain known lung cancer genes or cancer related genes in other cancer types. All genes contained in the 20 clusters are described in Additional File 6. Columns are as described in Table 1.
- §Gene annotations are based on hg18 human genome assembly.
- †MDM2 is located at chr12:67,488-67,520 KB and CCNE1 at chr19:34,500 KB.
- ‡Cancer related genes identified using the proposed method, not GISTIC.
