Figure 3From: Shape-based peak identification for ChIP-SeqAn overview of our method. In our method, aligned reads are extended to the average fragment length (for single end sequencing), and a coverage function records the number of extended reads containing each base pair. Trees capturing the shape of the coverage function are constructed and a tree shape statistic measuring the size of a maximal matching ℳ is computed. By comparison to a null model derived from the expected shape of random trees, significant peaks are identified.Back to article page