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Table 2 Comparison of the practical features of different web servers

From: PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality

 

Maximal number of mutations per querya

Number of mutations processed per minuted

  

1ag2

( N = 103)

3mbp

( N = 370)

1gog

( N = 689)

PoPMuSiC-2.1

19 × N b

6700

9000

4300

AutoMute [28]

19 × 5

13

4

1

CUPSAT [18]

19

600

600

600

D-mutant [17]

19

50

14

8

Eris [21]

1

< 0.1

< 0.1

< 0.1

I-mutant2.0 [24]

19c

8

7

6

Hunter [22]

1

0.4

0.3

0.2

PEAT-SA [23]

N b

40

44

41

  1. a N is the number of residues in the target protein. b These web servers also allow the submission of a mutation list. c This program is also available for download, which allows the creation of scripts for batch computations. d Each presented value was obtained after averaging over three queries submitted to the corresponding web server. Obviously, the speed of the computations may depend on the load of the server at the time of the query. The presented values should therefore not be viewed as anything more than rough estimations.