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Table 1 The number of two-locus unfaithfulness associations identified from seven diseases data sets under different constraints.

From: A hidden two-locus disease association pattern in genome-wide association studies

  BD CAD CD HT RA T1D T2D
T 1 48 31 25 46 132 153 67
T 2 52 35 28 51 153 204 80
T 3 60 36 29 52 165 252 84
T1 & Dist 0 0 0 1 1 1 0
T2 & Dist 0 0 0 3 17 17 0
T 3 & Dist 0 0 0 0 4 35 0
  1. T1 - the threshold of Bonferroni-corrected P-value is 0.10; T2 - the threshold of Bonferroni-corrected P-value is 0.20; T3 - the threshold of Bonferroni-corrected P-value is 0.30; Dist - the physical distance threshold between two SNPs is at least 1 Mb. This threshold is used to see how many unfaithfulness associations involving two remote loci