Distances among four selected points in each cluster. Dotted lines are coloured according to clustering reported in Figure 7. The same distances in the WT SH3 structure are reported in black dotted lines. The X-ray structure of the WT SH3, taken as a reference, is represented by grey cartoons and superimposed onto each graph. Points A, B, C, D, are the Cα atom positions in the representative conformation of each cluster of the following residues: A = L12; B = S36 in the n-src loop; C = D48 in the distal loop; D = P20 at the tip of the RT loop.