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Table 2 The mean MCC and BDT raw scores and Z-scores obtained by FunFOLD are compared with those obtained by each CASP8 function prediction group - as in Table 1 except for CASP8 targets containing only metal ligand s.

From: FunFOLD: an improved automated method for the prediction of ligand binding residues using 3D models of proteins

Group ID

N

Mean score for group

Mean score for FunFOLD

Increase in mean score

Mean Z-score for group

Mean Z-score for FunFOLD

P-value

(raw score)

P-value

(Z-score)

1 - p-value

(raw score)

1 - p-value

(Z-score)

  

MCC

BDT

MCC

BDT

MCC

BDT

MCC

BDT

MCC

BDT

MCC

BDT

MCC

BDT

MCC

BDT

MCC

BDT

FN407

14

0.764

0.981

0.799

0.710

0.035

0.029

1.064

1.099

1.197

1.218

0.541

0.447

0.541

0.553

0.459

0.553

0.459

0.447

FN202

14

0.654

0.582

0.798

0.761

0.145

0.233

0.869

0.803

1.185

1.349

0.025

0.009

0.047

0.035

0.975

0.991

0.953

0.965

FN034

13

0.620

0.460

0.862

0.819

0.241

0.359

0.641

0.430

1.330

1.522

0.007

0.002

0.005

0.002

0.993

0.998

0.995

0.998

FN417

15

0.143

0.283

0.744

0.710

0.331

0.427

0.183

-0.050

1.070

1.218

0.002

0.001

0.004

0.001

0.998

0.999

0.996

0.999

FN450

15

0.302

0.198

0.744

0.710

0.441

0.512

0.070

-0.077

1.070

1.218

0.000

0.000

0.028

0.032

1.000

1.000

0.972

0.968

FN325

14

0.367

0.318

0.798

0.761

0.432

0.443

0.055

0.052

1.185

1.349

0.002

0.002

0.005

0.005

0.998

0.998

0.995

0.995

FN057

13

0.201

0.189

0.783

0.742

0.582

0.553

-0.470

-0.446

1.165

1.324

0.000

0.000

0.000

0.000

1.000

1.000

1.000

1.000

FN163

12

0.178

0.169

0.685

0.647

0.507

0.478

-0.485

-0.444

0.976

1.110

0.000

0.001

0.000

0.001

1.000

0.999

1.000

0.999

FN483

12

0.066

0.071

0.699

0.656

0.633

0.585

-0.546

-0.552

1.023

1.116

0.001

0.001

0.008

0.002

0.999

0.999

0.992

0.998

FN108

13

0.119

0.092

0.783

0.761

0.664

0.669

-0.566

-0.594

1.172

1.349

0.000

0.000

0.001

0.001

1.000

1.000

0.999

0.999

FN242

15

0.138

0.157

0.744

0.710

0.609

0.554

-0.583

-0.437

1.070

1.218

0.000

0.000

0.000

0.000

1.000

1.000

1.000

1.000

FN105

15

0.004

0.030

0.744

0.710

0.739

0.680

-0.929

-0.818

1.070

1.218

0.000

0.000

0.000

0.000

1.000

1.000

1.000

1.000

FN086

13

-0.017

0.025

0.805

0.760

0.822

0.735

-1.092

-0.884

1.228

1.394

0.000

0.000

0.000

0.000

1.000

1.000

1.000

1.000