FunFOLD: an improved automated method for the prediction of ligand binding residues using 3D models of proteins

Roche, Daniel B; Tetchner, Stuart J; McGuffin, Liam J

doi:10.1186/1471-2105-12-160

BMC Bioinformatics

Table 7 The mean MCC and BDT raw scores and Z-scores obtained by FunFOLD are compared with those obtained by the top CASP9 function prediction groups - as in Table 6 except for CASP9 targets containing only metal ligand s.

From: FunFOLD: an improved automated method for the prediction of ligand binding residues using 3D models of proteins

Group ID	N	Mean score for group		Mean score for FunFOLD		Difference in mean score		Mean Z-score for group		Mean Z-score for FunFOLD		P-value (raw score)		P-value (Z-score)		1 - p-value (raw score)		1 - p-value (Z-score)
		MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT
FN114	6	0.642	0.560	0.408	0.343	-0.234	-0.217	0.602	0.777	-0.264	-0.275	0.947	0.970	0.911	0.947	0.053	0.030	0.089	0.053
FN094	6	0.651	0.521	0.530	0.428	-0.122	-0.092	0.555	0.551	0.210	0.159	0.860	0.860	0.791	0.860	0.140	0.140	0.209	0.140
FN452	6	0.626	0.518	0.492	0.397	-0.134	-0.121	0.417	0.491	-0.079	-0.104	0.911	0.860	0.911	0.911	0.089	0.140	0.089	0.089
FN242	7	0.540	0.438	0.450	0.367	-0.089	-0.071	0.381	0.369	-0.063	-0.044	0.911	0.735	0.911	0.799	0.089	0.265	0.089	0.201
FN339	7	0.536	0.424	0.450	0.367	-0.085	-0.057	0.345	0.406	-0.063	-0.044	0.853	0.735	0.799	0.896	0.147	0.265	0.201	0.104
FN096	7	0.562	0.420	0.450	0.367	-0.112	-0.053	0.258	0.207	-0.063	-0.044	0.853	0.663	0.735	0.853	0.147	0.337	0.265	0.147
FN236	7	0.470	0.369	0.450	0.367	-0.019	-0.002	-0.009	-0.065	-0.063	-0.044	0.606	0.606	0.606	0.500	0.394	0.394	0.394	0.500
FN057	6	0.371	0.250	0.530	0.428	0.158	0.178	-0.565	-0.770	0.210	0.159	0.109	0.031	0.156	0.031	0.891	0.969	0.844	0.969
FN072	6	0.360	0.239	0.530	0.428	0.170	0.189	-0.571	-0.817	0.210	0.159	0.109	0.047	0.156	0.031	0.891	0.953	0.844	0.969
FN425	7	0.281	0.226	0.450	0.367	0.169	0.142	-0.626	-0.546	-0.063	-0.044	0.209	0.089	0.209	0.140	0.791	0.911	0.791	0.860
FN017	6	0.233	0.201	0.530	0.428	0.297	0.227	-1.143	-1.008	0.210	0.159	0.031	0.016	0.031	0.016	0.969	0.984	0.969	0.984
FN415	6	0.197	0.172	0.530	0.428	0.333	0.256	-1.356	-1.214	0.210	0.159	0.031	0.016	0.031	0.016	0.969	0.984	0.969	0.984

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ISSN: 1471-2105

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