Figure 2

TAFFEL user interface. The clustering trees represents the clustering result for the DE genes after 4 hours of forskolin treatment in HEK293T cells. The genes have been clustered by the GO terms (left) and TFs (right). The topmost box represents the whole gene set without clustering. Below that, each level represents clustering to two, three, or more clusters. The green outline indicates the cluster number selection by AIC and blue by dAIC. The clusters obtained from the IEA analysis with FDR p < 0.1 are highlighted with the light blue background on the right side of cluster box. The best intercorrelating clusters (cell morphogenesis cluster in the GO tree and COUP cluster in the TF tree) between the trees are connected with the bold line. Information at bottom shows enriched annotations (left list) and cluster genes (right list). Positive regulation of biosynthetic process related cluster is selected in the picture.