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Table 1 Statistically significant clusters in the forskolin (FSK) and up-regulated (sIA↑) and down-regulated (sIA↓) aneurysm datasets

From: TAFFEL: Independent Enrichment Analysis of gene sets

CLUSTER ANNOTATION P P LIST N N LIST
FSK GO 26 transcription from RNA polymerase II promoter 1.9E-21 8.2E-04 23 46
    positive regulation of macromolecule biosynthetic process 2.5E-21 5.7E-02 19 26
    positive regulation of gene expression 2.5E-21 2.4E-02 19 26
    HES-1 2.0E-02 7.2E-01 8 32
    AhR 2.9E-02 4.9E-02 15 123
FSK GO 50 macromolecule localization 8.9E-37 8.2E-02 39 49
    protein transport 8.9E-37 1.0E-01 37 43
    establishment of protein localization 8.9E-37 1.1E-01 37 43
    FOXO1 3.3E-02 5.1E-01 10 32
FSK TF 33 E2F-4_DP-2 4.2E-34 1.3E-01 31 48
    Rb_E2F-1_DP-1 4.2E-34 1.5E-01 30 43
    E2F-4_DP-1 6.2E-31 2.2E-02 29 45
    organelle organization 2.5E-03 4.0E-03 12 50
sIA ↑ GO 58 cation transport 3.8E-08 1.8E-01 17 23
    ion transport 3.8E-08 3.7E-01 18 26
    metal ion transport 1.2E-05 4.2E-01 12 16
    MTF-1 4.8E-02 4.7E-01 13 30
    ATF-1 4.8E-02 6.5E-01 9 17
sIA ↑ TF 29 S8 1.3E-19 8.5E-01 23 40
    Chx10 3.8E-14 7.3E-01 20 42
    Lhx3a 8.1E-13 6.7E-01 19 42
    amine biosynthetic process 9.1E-02 1.7E-01 3 4
sIA ↓ GO 22 nervous system development 1.3E-11 1.3E-02 17 32
    generation of neurons 2.1E-06 2.8E-01 8 10
    cell development 2.1E-06 2.8E-01 10 17
    Tal-1 3.1E-02 1.0E+00 4 5
    AR 9.4E-02 9.8E-01 6 17
sIA ↓ GO 49 organic acid metabolic process 1.3E-08 2.8E-01 13 13
    carboxylic acid metabolic process 1.3E-08 2.8E-01 13 13
    oxidation reduction 1.2E-07 2.8E-01 14 16
    lipid metabolic process 5.3E-07 4.4E-01 13 16
    NF-1 3.7E-02 9.8E-01 14 30
  1. CLUSTER column indicates the clustered dataset, annotations used for clustering (either GO or TF) and the size of the cluster, respectively. ANNOTATION column indicates enriched GO terms and TF annotations from TRANSFAC in each cluster. P and P LIST columns indicate Benjamini-Hochberg FDR corrected Fisher's exact test p-values for the enrichment of the annotation in the cluster and in the gene list, respectively. N and N LIST columns show the number of genes associated with the annotation in the cluster and in the gene list.