Table 1 Statistically significant clusters in the forskolin (FSK) and up-regulated (sIA↑) and down-regulated (sIA↓) aneurysm datasets

FSK

GO

26

transcription from RNA polymerase II promoter

1.9E-21

8.2E-04

23

46

positive regulation of macromolecule biosynthetic process

2.5E-21

5.7E-02

19

26

positive regulation of gene expression

2.5E-21

2.4E-02

19

26

HES-1

2.0E-02

7.2E-01

8

32

AhR

2.9E-02

4.9E-02

15

123

FSK

GO

50

macromolecule localization

8.9E-37

8.2E-02

39

49

protein transport

8.9E-37

1.0E-01

37

43

establishment of protein localization

8.9E-37

1.1E-01

37

43

FOXO1

3.3E-02

5.1E-01

10

32

FSK

TF

33

E2F-4_DP-2

4.2E-34

1.3E-01

31

48

Rb_E2F-1_DP-1

4.2E-34

1.5E-01

30

43

E2F-4_DP-1

6.2E-31

2.2E-02

29

45

organelle organization

2.5E-03

4.0E-03

12

50

sIA ↑

GO

58

cation transport

3.8E-08

1.8E-01

17

23

ion transport

3.8E-08

3.7E-01

18

26

metal ion transport

1.2E-05

4.2E-01

12

16

MTF-1

4.8E-02

4.7E-01

13

30

ATF-1

4.8E-02

6.5E-01

9

17

sIA ↑

TF

29

S8

1.3E-19

8.5E-01

23

40

Chx10

3.8E-14

7.3E-01

20

42

Lhx3a

8.1E-13

6.7E-01

19

42

amine biosynthetic process

9.1E-02

1.7E-01

3

4

sIA ↓

GO

22

nervous system development

1.3E-11

1.3E-02

17

32

generation of neurons

2.1E-06

2.8E-01

8

10

cell development

2.1E-06

2.8E-01

10

17

Tal-1

3.1E-02

1.0E+00

4

5

AR

9.4E-02

9.8E-01

6

17

sIA ↓

GO

49

organic acid metabolic process

1.3E-08

2.8E-01

13

13

carboxylic acid metabolic process

1.3E-08

2.8E-01

13

13

oxidation reduction

1.2E-07

2.8E-01

14

16

lipid metabolic process

5.3E-07

4.4E-01

13

16

NF-1

3.7E-02

9.8E-01

14

30