Figure 3

Transcriptional regulations in dendritic cells treated with LPS. (A) and (B) shows the transcriptional regulations between the two TRS Pathways at 2h and at 8h after the LPS treatment respectively. (A) At 2h after the treatment, TLR4 sensing LPS sends a signal to NFKB. NFKB reinforces to increase its own expression by increasing the mRNA expression level of TNF. (B) At 8h after the treatment, NFKB activates the JAK-STAT pathway through increasing the mRNA expression levels of IL6, IL12B, and OSM. The nodes represent proteins and their colors show their mRNA expression levels (the same as Figure 1). Light cyan colored boxes represent gene families. The black edges represent PPIs and red edges do positive PD interactions. The positive PD interactions are estimated based on the expression change of source and target genes.