Table 1 The results of TRS Network analysis.
From: Context-dependent transcriptional regulations between signal transduction pathways
Networks or pathways | Network score (p value) | S | P | |ε| |
|---|---|---|---|---|
TLR4 TRS Network | 4.312 (<1.0e-03) | 17.246 | 942.988 | 218 |
TNF TRS Network | 4.046 (<1.0e-03) | 17.509 | 698.589 | 214 |
TLR signaling pathway | 2.078 (0.38) | 5.173 | 32.789 | 213 |
Apoptosis | 1.385 (0.83) | 3.958 | 159.534 | 158 |
D2D network | 0.118 (0.99) | 29.244 | 32.089 | 834 |
jActiveModule network | -0.194 (0.99) | 41.025 | 19.484 | 970 |
- The network scores are calculated by summing InS
, and InP
and subtracting In|
| (See Eq. (5)). S indicates how much its nodes are differentially expressed. is calculated by summing the path scores of all TRS Pathways the network includes. P Sub-networks results are highlighted in bold to be easily recognized from KEGG pathway results. P values are assessed by random permutation of the expression of individual genes. The expression condition is 2h after the LPS treatment.
and subtracting In|
| (See Eq. (