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Table 1 Gene Sets Overlapping with the Detected Gene Cluster at a Proportion of ≥50%

From: A scan statistic to extract causal gene clusters from case-control genome-wide rare CNV data

Gene Set Name Overlap Proportion Gene Set Size
BIOCARTA_PROTEASOME_PATHWAY 0.63 19
REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 0.58 48
REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE 0.58 43
NGO_MALIGNANT_GLIOMA_1P_LOH 0.57 7
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION 0.57 58
REACTOME_SIGNALING_BY_WNT 0.57 58
REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0.57 23
REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21 0.56 52
REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G 0.55 47
BIOCARTA_SRCRPTP_PATHWAY 0.55 11
BIOCARTA_SET_PATHWAY 0.55 11
REACTOME_STABILIZATION_OF_P53 0.54 46
IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_DN 0.54 13
REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE 0.53 47
KEGG_PROTEASOME 0.52 48
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0.51 63
GILMORE_CORE_NFKB_PATHWAY 0.50 10
FIRESTEIN_CTNNB1_PATHWAY_AND_PROLIFERATION 0.50 8
KUROKAWA_LIVER_CANCER_EARLY_RECURRENCE_DN 0.50 6
BIOCARTA_CDMAC_PATHWAY 0.50 16
REACTOME_SHC_MEDIATED_SIGNALLING 0.50 12
  1. This table lists the gene sets with an overlapping proportion ≥50% for the gene cluster detected by the proposed test. For this analysis, we used all 3272 curated gene sets in MsigDB (ver 3.0) [24].