Table 4 Significantly changed TFAs under isobutanol condition predicted by GTRNetwork reconstructed gene regulatory network The reconstructed gene regulatory network includes 381 potential new regulatory links, the 16 significantly changed TFAs predicted by original RegulonDB data from Brynildsen's paper [39] are not included.

argA, gltF, argE, argH, rimP, rbfA, truB, rpsO, pnp, nusA, infB, hisP, gltD, gltB, carB, artP, artI, artQ, artM, artJ, hisJ, hisQ, metY, astE, astB, astD, astA, astC, hisM, argB, argC, argD, argF, argG, argI, argR, carA

ascB, ascF, ascG, htpG, prpR, clpB, dnaJ, dnaK, tpke11, groL, groS, grpE, hslU, hslV, ybbN, lipB, ybeD, lnt, ybeX, ybeY, ybeZ

tauA, tauB, tauC, ssuC, ssuD, ssuA, ssuE, hslJ , cbl , tauD, ssuB, cysP, cysU, cysW , cysN , cysM , cysK , cysJ , cysI , cysH , cysD , cysC, cysB , cysA, gsiA, gsiB, gsiC, gsiD, iaaA , yciW , ydjN, yeeD, yeeE

lhgO, alaT, alaU, alaV, gltT, gltU, gltV, gltW, ileT, ileU, ileV, micF , rrfA, rrfB, rrfC, rrfD, rrfE, rrfG, rrfH, rrlA, rrlB, rrlC, rrlD, rrlE, rrlG, rrlH, rrsA, rrsB, rrsC, rrsD, rrsE, rrsG, rrsH, rrfF, thrV, csiD, ilvX, adhE, aroA , fimA, fimC, fimD, fimE, fimF, fimG, fimH, gabT, gcvH , gltB , gltD , ilvA, ilvD , ilvE, ilvH, ilvH, ilvI, ilvM , kbl, livF , livG , livH , livJ, livK , livM , lrp, lysU, malT , ompC, ompF , oppA , oppB , oppC , oppD , oppF , osmC , sdaA , serA, serC , tdh , argO, ilvL, gabD, gabP, osmY , hdeA , hdeB , yhiD, dadA, dadX , gcvT , gltF , stpA , gcvP, aidB , fimI, yeiL, yojI, gdhA, ilvG_1, ilvG_2, thrA, thrB, thrC , thrL

pqiB, pqiA, ybaO , nfsB, micF , slp , dctR, acrB , acrA, marB, marR, marA , inaA , rfaY, rfaZ, yhiD, hdeB , hdeA , rob , zwf , fumC , fpr, nfo, poxB , purA, putA, sodA , tolC, ygiA , ygiB, ygiC , ltaE, ybjT, talA , tktB , phr, ybgA , yhbW

metF, metK , metL, metR , yeiB, folE , ahpC, ahpF, metQ, metN, metI, metA , metB, metC , metE

nadA, pnuC, pncB, nadB