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Table 1 General comparison of different approaches to flux coupling analysis

From: FFCA: a feasibility-based method for flux coupling analysis of metabolic networks

Method name Preprocessing Type of linear program
and solution
Further distinguishing of partial
and full coupling required?
Postprocessing for
reversible reactions?
MMB-FCA computing MMBs + reaction classification n/a No No
EFP-FCA splitting reversible reactions MILP, optimal Yes Yes
FCF splitting reversible reactions LP, optimal No Yes
W-FCF n/a LP, optimal No No
WR-FCF/WRP-FCF reaction classification LP, optimal No No
FFCA reaction classification LP, feasible Yes No