Figure 2

Top scoring regulatory relationships and discretized data patterns. Each grid in (A) and (B) shows the nine possible state combinations in which each pair of variables is observed in the discretized expression data. In the regulatory networks, the dotted ovals represent regulators while the solid ovals represent target genes. (A) RLN1 and RLN2 expression and regulatory network. Note that RLN1 and RLN2 show a nearly linear co-expression pattern. (B) PGC and GDF15 expression and regulatory network. The expression pattern of PGC relative to GDF15 does not show a linear pattern, but still scores well in the multinomial model used by RegNetB.