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Table 2 Interface Residue Prediction Performance of NPS-HomPPI on Benchmark180.

From: HomPPI: a class of sequence homology based protein-protein interface prediction methods

Binding Type Homology Zone Prediction Coverage CCP SensitivityP SpecificityP AccuracyP
Enzyme-inhibitor,- Transient Safe/Twilight 67% (24/36) 0.53 0.67 0.58 0.86
Non-enzyme-inhibitor-Transient (NEIT) Safe/Twilight 60% (18/30) 0.45 0.54 0.58 0.83
Hetero-dimer - Obligate Safe/Twilight 85% (23/27) 0.63 0.72 0.69 0.88
Homo-dimer - Obligate Safe/Twiight 69% (60/87) 0.76 0.83 0.78 0.94
  1. Prediction coverage reflects that predictions are made only on proteins for which HomPPI can identify Safe/Twilight Zone homologs.