Figure 2

Functional enrichment. The matrix shows GO terms enriched with high confidence (FDR ≤ 0.01, indicated in blue, and FWER ≤ 0.5; identified using GSEA [33]) in the genes more activated in the damaged cells by ATM, RelA and p53 (left three columns) and in the genes more activated in the healthy cells (right three columns). Each GO term shown is enriched in at least one column. The terms were grouped into functional clusters with names indicated on the left (Methods), and sorted by the average enrichment in the first three columns. The GO term enrichment is mutually exclusive for the genes more activated in the healthy and in the damaged cells. Eleven functional clusters of GO terms are enriched exclusively in genes more activated in the damaged, and two exclusively in the healthy cells. Abbreviations: mtbl, metabolic; nc, nucleo; pol, polymerase; reg, regulation; neg, negative; pos, positive; proc, process; arch, architecture; nnnna, nucleobase, nucleoside, nucleotide, and nucleic acid. The identified clusters confirm that the dominant deregulation scores are correlated with a functionality which is highly relevant to the switch between the compared cell populations.