Figure 6

Effect of query signature size on SPEC accuracy. The B cell-specific disease signature was trimmed to the size indicated on the x-axis by removing the least differentially-expressed genes. SPEC was then applied to the SLE dataset in order to identify the source of this query signature using the detailed cell subsets. Predictions were considered correct (filled circles) when the most likely subset was determined as B cells, and incorrect otherwise (empty circles). The dashed line indicates a p-value cutoff of 0.05.