TY - JOUR AU - Rakovski, Cyril AU - Weisenberger, Daniel J. AU - Marjoram, Paul AU - Laird, Peter W. AU - Siegmund, Kimberly D. PY - 2011 DA - 2011/07/13 TI - Modeling measurement error in tumor characterization studies JO - BMC Bioinformatics SP - 284 VL - 12 IS - 1 AB - Etiologic studies of cancer increasingly use molecular features such as gene expression, DNA methylation and sequence mutation to subclassify the cancer type. In large population-based studies, the tumor tissues available for study are archival specimens that provide variable amounts of amplifiable DNA for molecular analysis. As molecular features measured from small amounts of tumor DNA are inherently noisy, we propose a novel approach to improve statistical efficiency when comparing groups of samples. We illustrate the phenomenon using the MethyLight technology, applying our proposed analysis to compare MLH1 DNA methylation levels in males and females studied in the Colon Cancer Family Registry. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-12-284 DO - 10.1186/1471-2105-12-284 ID - Rakovski2011 ER -