Statistical Mutation Calling from Sequenced Overlapping DNA Pools in TILLING Experiments

BMC Bioinformatics

Table 3 Performance comparison of CAMBa to other methods using default parameters on Wheat with increased variance

Method	Wheat with increased variance
	Pred	Conf	FP	FN	Sens	Spec
CAMBa	113	28	36	30	71.96	99.21
Outlier	113	20	58	52	51.40	98.73
CRISP	86	25	17	38	64.49	99.63
VarScan
ComSeq	743	30	661	25	76.64	85.51
Poisson	60	18	11	58	45.79	99.76

Performance comparison of CAMBa to other methods using default parameters, on the Wheat data set after artificially increasing the coverage variance. The column abbreviations are as in Table 1. All methods are evaluated on their ability to predict the carrier of each candidate mutation, except CRISP, which cannot make such predictions. We were unable to report results for VarScan due to technical issues in generating a modified pileup of reads.

ISSN: 1471-2105