TY - JOUR AU - Jung, Klaus AU - Friede, Tim AU - Beißbarth, Tim PY - 2011 DA - 2011/07/15 TI - Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes JO - BMC Bioinformatics SP - 288 VL - 12 IS - 1 AB - Gene expression experiments are common in molecular biology, for example in order to identify genes which play a certain role in a specified biological framework. For that purpose expression levels of several thousand genes are measured simultaneously using DNA microarrays. Comparing two distinct groups of tissue samples to detect those genes which are differentially expressed one statistical test per gene is performed, and resulting p-values are adjusted to control the false discovery rate. In addition, the expression change of each gene is quantified by some effect measure, typically the log fold change. In certain cases, however, a gene with a significant p-value can have a rather small fold change while in other cases a non-significant gene can have a rather large fold change. The biological relevance of the change of gene expression can be more intuitively judged by a fold change then merely by a p-value. Therefore, confidence intervals for the log fold change which accompany the adjusted p-values are desirable. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-12-288 DO - 10.1186/1471-2105-12-288 ID - Jung2011 ER -