Figure 6

Comparison of network reconstruction without and with prior knowledge incorporation for data set hcc1954. Comparison of the network inferred using the GA and BIC score optimisation (left, adapted from Bender et. al. [9]) and using inhibMCMC together with the Laplace prior, λ = 0.0025 (right). Using the prior results in correct identification of signalling cascades like MAPK (EGF→ERBB1→MEK12→ERK12→p70S6K) or PI3K/AKT (HRG→ERBB3→PDK1→AKT). Additionally, two new edges were found, marked in blue (ERK12→p38 and PKC⊣AKT). These reflect changes in the connectivity that were strongly supported by the data and that were inferred although not included in the reference.