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Table 5 More # of non-H, # of 2-degree cyclic atoms, degree of cyclization and # of non-H polar bonds could increase the potency of HIV Integrase Inhibitors.

From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study

Precursor

Structure

pKi

#11

pIC50: 5.82

+ 0.75%

(× 21.2)

#189

pIC50: 5.53

+ 0.74%

(× 21.2)

#188

pIC50: 4.43

+ 0.73%

(× 21.3)