Table 5 More # of non-H, # of 2-degree cyclic atoms, degree of cyclization and # of non-H polar bonds could increase the potency of HIV Integrase Inhibitors.
From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study
Precursor | Structure | pKi | |
|---|---|---|---|
#11 pIC50: 5.82 |
|
| + 0.75% (× 21.2) |
#189 pIC50: 5.53 |
|
| + 0.74% (× 21.2) |
#188 pIC50: 4.43 |
|
| + 0.73% (× 21.3) |
